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随机点积图潜在位置的高效一步估计AI 解读

We propose a one-step procedure to estimate the latent positions in random dot product graphs efficiently. Unlike the classical spectral-based methods, the proposed one-step procedure takes advantage of both the low-rank structure of the expected adjacency matrix and the Bernoulli likelihood information of the sampling model simultaneously. We show that for each vertex, the corresponding row of the one-step estimator (OSE) converges to a multivariate normal distribution…

计算机模型的贝叶斯投影校准AI 解读

We develop a Bayesian approach called the Bayesian projected calibration to address the problem of calibrating an imperfect computer model using observational data from an unknown complex physical system. The calibration parameter and the physical system are parameterized in an identifiable fashion via the L2-projection. The physical system is imposed a Gaussian process prior distribution, which naturally induces a prior distribution on the calibration parameter through the…

随机点积图潜在位置的最优贝叶斯估计AI 解读

Summary We propose and prove the optimality of a Bayesian approach for estimating the latent positions in random dot product graphs, which we call posterior spectral embedding. Unlike classical spectral-based adjacency, or Laplacian spectral embedding, posterior spectral embedding is a fully likelihood-based graph estimation method that takes advantage of the Bernoulli likelihood information of the observed adjacency matrix. We develop a minimax lower bound for estimating…

贝叶斯排斥型高斯混合模型AI 解读

We develop a general class of Bayesian repulsive Gaussian mixture models that encourage well-separated clusters, aiming at reducing potentially redundant components produced by independent priors for locations (such as the Dirichlet process). The asymptotic results for the posterior distribution of the proposed models are derived, including posterior consistency and posterior contraction rate in the context of nonparametric density estimation. More importantly, we show that…

带序贯转移时间的动态治疗方案的贝叶斯非参数估计AI 解读

We analyze a dataset arising from a clinical trial involving multi-stage chemotherapy regimes for acute leukemia. The trial design was a 2 × 2 factorial for frontline therapies only. Motivated by the idea that subsequent salvage treatments affect survival time, we model therapy as a dynamic treatment regime (DTR), that is, an alternating sequence of adaptive treatments or other actions and transition times between disease states. These sequences may vary substantially…

We propose small-variance asymptotic approximations for inference on tumor heterogeneity (TH) using next-generation sequencing data. Understanding TH is an important and open research problem in biology. The lack of appropriate statistical inference is a critical gap in existing methods that the proposed approach aims to fill. We build on a hierarchical model with an exponential family likelihood and a feature allocation prior. The proposed implementation of posterior…