Differential Markov random field analysis with an application to detecting differential microbial community networks
差异马尔可夫随机场分析及微生物群落网络差异检测
Micro-organisms such as bacteria form complex ecological community networks that can be greatly influenced by diet and other environmental factors. Differential analysis of microbial community structures aims to elucidate systematic changes during an adaptive response to changes in environment. In this paper, we propose a flexible Markov random field model for microbial network structure and introduce a hypothesis testing framework for detecting differences between networks,…