Parametric estimation procedures for screening programmes: stable and nonstable disease models for multimodality case finding
筛查项目的参数估计：多方式病例发现的稳定与非稳定疾病模型
This paper develops methods for estimating the parameters associated with early detection programmes. Disease is considered to have three states: a disease-free state or a state in which the disease cannot be detected, a preclinical state and a clinical state. The natural history of the disease is assumed to be progressive. The parameters to be estimated are the sensitivity of one or two disease detection modalities and the characteristics of the preclinical sojourn time…