Sufficient direction factor model and its application to gene expression quantitative trait loci discovery
充分方向因子模型及其在基因表达数量性状位点发现中的应用
Rapid improvement in technology has made it relatively cheap to collect genetic data, however statistical analysis of existing data is still much cheaper. Thus, secondary analysis of single-nucleotide polymorphism, SNP, data, i.e., reanalysing existing data in an effort to extract more information, is an attractive and cost-effective alternative to collecting new data. We study the relationship between gene expression and SNPs through a combination of factor analysis and…