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利用深度神经网络对删失数据进行非参数推断AI 解读

Abstract We propose a novel deep learning approach to nonparametric statistical inference for the conditional hazard function of survival time with right-censored data. We use a deep neural network (DNN) to approximate the logarithm of a conditional hazard function given covariates and obtain a DNN likelihood-based estimator of the conditional hazard function. Such an estimation approach enhances model flexibility and hence relaxes structural and functional assumptions on…

核方法与筛方法结合：稀疏纵向协变量下的变换风险模型AI 解读

We study the transformed hazards model with time-dependent covariates observed intermittently for the censored outcome. Existing work assumes the availability of the whole trajectory of the time-dependent covariates, which is unrealistic. We propose combining kernel-weighted log-likelihood and sieve maximum log-likelihood estimation to conduct statistical inference. The method is robust and easy to implement. We establish the asymptotic properties of the proposed estimator…

用于筛估计的相位型分布AI 解读

In many semiparametric models, the infinite-dimensional parameter of direct interest is a probability density, but its nonparametric estimation is usually difficult in the presence of incomplete data. To address this issue, this study promotes phase-type distributions as a method of sieve. Phase-type distributions are dense in the space of nonnegative distributions, closed under minimum, maximum, and convolution, and compatible with the accelerated failure time model. This…

函数型加速失效时间模型的有效估计AI 解读

Summary We propose a functional accelerated failure time model to characterize the effects of both functional and scalar covariates on the time to event of interest, and provide regularity conditions to guarantee model identifiability. For efficient estimation of model parameters, we develop a sieve maximum likelihood approach where parametric and nonparametric coefficients are bundled with an unknown baseline hazard function in the likelihood function. Not only do the…

高维单指标模型假设检验的随机投影方法AI 解读

In this article, we consider the problem of hypothesis testing in high-dimensional single-index models. First, we study the feasibility of applying the classical F-test to a single-index model when the dimension of covariate vector and sample size are of the same order, and derive its asymptotic null distribution and asymptotic local power function. For the ultrahigh-dimensional single-index model, we construct F-statistics based on lower-dimensional random projections of…

函数型 Cox 模型的半参数推断AI 解读

This article studies penalized semiparametric maximum partial likelihood estimation and hypothesis testing for the functional Cox model in analyzing right-censored data with both functional and scalar predictors. Deriving the asymptotic joint distribution of finite-dimensional and infinite-dimensional estimators is a very challenging theoretical problem due to the complexity of semiparametric models. For the problem, we construct the Sobolev space equipped with a special…

删失数据下估计方程数量增长的惩罚广义经验似然AI 解读

This article considers simultaneous variable selection and parameter estimation as well as hypothesis testing in censored survival models where a parametric likelihood is not available. For the problem, we utilize certain growing dimensional general estimating equations and propose a penalized generalized empirical likelihood, where the general estimating equations are constructed based on the semiparametric efficiency bound of estimation with given moment conditions. The…

信息性观测时点下畸变纵向数据的协变量调整回归AI 解读

In many longitudinal studies, repeated response and predictors are not directly observed, but can be treated as distorted by unknown functions of a common confounding covariate. Moreover, longitudinal data involve an observation process which may be informative with a longitudinal response process in practice. To deal with such complex data, we propose a class of flexible semiparametric covariate-adjusted joint models. The new models not only allow for the longitudinal…

单调函数的中等偏差与非参数推断AI 解读

This paper considers self-normalized limits and moderate deviations of nonparametric maximum likelihood estimators for monotone functions. We obtain their self-normalized Cramér-type moderate deviations and limit distribution theorems for the nonparametric maximum likelihood estimator in the current status model and the Grenander-type estimator. As applications of the results, we present a new procedure to construct asymptotical confidence intervals and asymptotical…

The delta method is a popular and elementary tool for deriving limiting distributions of transformed statistics, while applications of asymptotic distributions do not allow one to obtain desirable accuracy of approximation for tail probabilities. The large and moderate deviation theory can achieve this goal. Motivated by the delta method in weak convergence, a general delta method in large deviations is proposed. The new method can be widely applied to driving the moderate…

面板计数数据的多样本非参数检验新方法AI 解读

This paper considers the problem of multi-sample nonparametric comparison of counting processes with panel count data, which arise naturally when recurrent events are considered. Such data frequently occur in medical follow-up studies and reliability experiments, for example. For the problem considered, we construct two new classes of nonparametric test statistics based on the accumulated weighted differences between the rates of increase of the estimated mean functions of…

信息性观测时点下纵向数据的半参数回归分析AI 解读

Statistical analysis of longitudinal data has been discussed by many authors, and a number of methods have been proposed. Most of the research have focused on situations where observation times are independent of or carry no information about the response variable and therefore rely on conditional inference procedures given the observation times. This article considers a different situation, where the independence assumption may not hold; that is, the observation times may…