Elastic integrative analysis of randomised trial and real-world data for treatment heterogeneity estimation
随机试验与真实世界数据的弹性整合：处理效应异质性估计
Abstract We propose a test-based elastic integrative analysis of the randomised trial and real-world data to estimate treatment effect heterogeneity with a vector of known effect modifiers. When the real-world data are not subject to bias, our approach combines the trial and real-world data for efficient estimation. Utilising the trial design, we construct a test to decide whether or not to use real-world data. We characterise the asymptotic distribution of the test-based…