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加权平均生存检验统计量：删失生存数据的一类距离检验AI 解读

Summary A class of test statistics is introduced which is sensitive against the alternative of stochastic ordering in the two-sample censored data problem. The test statistics for evaluating a cumulative weighted difference in survival distributions are developed while taking into account the imbalances in base-line covariates between two groups. This procedure can be used to test the null hypothesis of no treatment effect, especially when base-line hazards cross and…

利用替代失效时间数据提高临床试验的成本效益AI 解读

In clinical trials with failure time, outcomes, the cost of follow-up for the endpoint of primary interest is sometimes expensive. In many of these settings, one or more secondary or surrogate failure time outcomes are also available which either occur much earlier or are much less expensive to follow than the primary outcome. This paper presents a method for using these secondary outcomes to increase the power of detecting a treatment effect on the primary outcome only,…

利用替代失效时间数据提高临床试验的成本效益AI 解读

In clinical trials with failure time, outcomes, the cost of follow-up for the endpoint of primary interest is sometimes expensive. In many of these settings, one or more secondary or surrogate failure time outcomes are also available which either occur much earlier or are much less expensive to follow than the primary outcome. This paper presents a method for using these secondary outcomes to increase the power of detecting a treatment effect on the primary outcome only,…