Analysis of Time-to-Event Data With Incomplete Event Adjudication
事件判定不完整时的事件发生时间数据分析
In many multicenter, randomized clinical trials, the primary outcome is the time to the first of a number of possible clinical events. An event classification committee may be convened to determine whether events that have been reported by investigators meet the predetermined criteria for primary endpoint events. When interim analyses are performed in such trials, the final classification for many reported events will not be known. Failure to account for the uncertain status…