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Regression analysis of group-tested current status data

混合样本检测的现状数据回归分析

Summary Group testing is an effective way to reduce the time and cost associated with conducting large-scale screening for infectious diseases. Benefits are realized through testing pools formed by combining specimens, such as blood or urine, from different individuals. In some studies, individuals are assessed only once and a time-to-event endpoint is recorded, for example, the time until infection. Combining group testing with this type of endpoint results in group-tested…

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A Sieve Semiparametric Maximum Likelihood Approach for Regression Analysis of Bivariate Interval-Censored Failure Time Data

双变量区间删失失效时间回归的筛半参数极大似然方法

Interval-censored failure time data arise in a number of fields and many authors have discussed various issues related to their analysis. However, most of the existing methods are for univariate data and there exists only limited research on bivariate data, especially on regression analysis of bivariate interval-censored data. We present a class of semiparametric transformation models for the problem and for inference, a sieve maximum likelihood approach is developed. The…

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Sieve maximum likelihood regression analysis of dependent current status data

依赖型现状数据的筛最大似然回归分析

Current status data occur in contexts including demographic studies and tumorigenicity experiments. In such cases, each subject is observed only once and the failure time of interest is either left- or right-censored (Kalbfleisch & Prentice, 2002). Many methods have been developed for the analysis of such data (Huang, 1996; Sun, 2006), most of which assume that the failure time and the observation time are independent completely or given covariates. In this paper, we present…

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