Nonparametric Estimation for Censored Mixture Data With Application to the Cooperative Huntington’s Observational Research Trial
删失混合数据的非参数估计及亨廷顿病观察研究应用
This work presents methods for estimating genotype-specific distributions from genetic epidemiology studies where the event times are subject to right censoring, the genotypes are not directly observed, and the data arise from a mixture of scientifically meaningful subpopulations. Examples of such studies include kin-cohort studies and quantitative trait locus (QTL) studies. Current methods for analyzing censored mixture data include two types of nonparametric maximum…