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Global testing against sparse alternatives in time-frequency analysis

时频分析中针对稀疏备择的全局检验

In this paper, an over-sampled periodogram higher criticism (OPHC) test is proposed for the global detection of sparse periodic effects in a complex-valued time series. An explicit minimax detection boundary is established between the rareness and weakness of the complex sinusoids hidden in the series. The OPHC test is shown to be asymptotically powerful in the detectable region. Numerical simulations illustrate and verify the effectiveness of the proposed test. Furthermore,…

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Structured Matrix Completion with Applications to Genomic Data Integration

结构化矩阵补全及其基因组数据整合应用

Matrix completion has attracted significant recent attention in many fields including statistics, applied mathematics and electrical engineering. Current literature on matrix completion focuses primarily on independent sampling models under which the individual observed entries are sampled independently. Motivated by applications in genomic data integration, we propose a new framework of structured matrix completion (SMC) to treat structured missingness by design.…

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Estimating sparse precision matrix: Optimal rates of convergence and adaptive estimation

稀疏精度矩阵估计:最优收敛率与自适应估计

Precision matrix is of significant importance in a wide range of applications in multivariate analysis. This paper considers adaptive minimax estimation of sparse precision matrices in the high dimensional setting. Optimal rates of convergence are established for a range of matrix norm losses. A fully data driven estimator based on adaptive constrained $\ell_{1}$ minimization is proposed and its rate of convergence is obtained over a collection of parameter spaces. The…

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Large-Scale Multiple Testing of Correlations

Multiple testing of correlations arises in many applications including gene coexpression network analysis and brain connectivity analysis. In this paper, we consider large scale simultaneous testing for correlations in both the one-sample and two-sample settings. New multiple testing procedures are proposed and a bootstrap method is introduced for estimating the proportion of the nulls falsely rejected among all the true nulls. The properties of the proposed procedures are…

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Minimax and Adaptive Estimation of Covariance Operator for Random Variables Observed on a Lattice Graph

格点图观测随机变量的协方差算子极小极大与自适应估计

Covariance structure plays an important role in high-dimensional statistical inference. In a range of applications including imaging analysis and fMRI studies, random variables are observed on a lattice graph. In such a setting, it is important to account for the lattice structure when estimating the covariance operator. In this article, we consider both minimax and adaptive estimation of the covariance operator over collections of polynomially decaying and exponentially…

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Instrumental Variables Estimation With Some Invalid Instruments and its Application to Mendelian Randomization

部分工具变量无效时的工具变量估计及孟德尔随机化应用

Instrumental variables have been widely used for estimating the causal effect between exposure and outcome. Conventional estimation methods require complete knowledge about all the instruments’ validity; a valid instrument must not have a direct effect on the outcome and not be related to unmeasured confounders. Often, this is impractical as highlighted by Mendelian randomization studies where genetic markers are used as instruments and complete knowledge about instruments’…

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Testing differential networks with applications to the detection of gene-gene interactions

差异网络检验及其在基因交互识别中的应用

Model organisms and human studies have yielded increasing empirical evidence that interactions among genes contribute broadly to genetic variation of complex traits. In the presence of gene-gene interactions, the dimensionality of the feature space becomes extremely high relative to the sample size. This poses a significant methodological challenge in the identification of gene-gene interactions. In this paper, by using a Gaussian graphical model framework, we translate the…

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ROP: Matrix recovery via rank-one projections

ROP:通过秩一投影恢复矩阵

Estimation of low-rank matrices is of significant interest in a range of contemporary applications. In this paper, we introduce a rank-one projection model for low-rank matrix recovery and propose a constrained nuclear norm minimization method for stable recovery of low-rank matrices in the noisy case. The procedure is adaptive to the rank and robust against small perturbations. Both upper and lower bounds for the estimation accuracy under the Frobenius norm loss are…

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False Discovery Control in Large-Scale Spatial Multiple Testing

大规模空间多重检验中的错误发现控制

Summary The paper develops a unified theoretical and computational framework for false discovery control in multiple testing of spatial signals. We consider both pointwise and clusterwise spatial analyses, and derive oracle procedures which optimally control the false discovery rate, false discovery exceedance and false cluster rate. A data-driven finite approximation strategy is developed to mimic the oracle procedures on a continuous spatial domain. Our multiple-testing…

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Adaptive Confidence Bands for Nonparametric Regression Functions

非参数回归函数的自适应置信带

A new formulation for the construction of adaptive confidence bands in non-parametric function estimation problems is proposed. Confidence bands are constructed which have size that adapts to the smoothness of the function while guaranteeing that both the relative excess mass of the function lying outside the band and the measure of the set of points where the function lies outside the band are small. It is shown that the bands adapt over a maximum range of Lipschitz…

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Two-Sample Test of High Dimensional Means Under Dependence

变量相关情形下高维均值的两样本检验

Summary The paper considers in the high dimensional setting a canonical testing problem in multivariate analysis, namely testing the equality of two mean vectors. We introduce a new test statistic that is based on a linear transformation of the data by the precision matrix which incorporates the correlations between the variables. The limiting null distribution of the test statistic and the power of the test are analysed. It is shown that the test is particularly powerful…

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Sparse PCA: Optimal rates and adaptive estimation

稀疏主成分分析:最优收敛率与自适应估计

Principal component analysis (PCA) is one of the most commonly used statistical procedures with a wide range of applications. This paper considers both minimax and adaptive estimation of the principal subspace in the high dimensional setting. Under mild technical conditions, we first establish the optimal rates of convergence for estimating the principal subspace which are sharp with respect to all the parameters, thus providing a complete characterization of the difficulty…

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Adaptive confidence intervals for regression functions under shape constraints

形状约束下回归函数的自适应置信区间

Adaptive confidence intervals for regression functions are constructed under shape constraints of monotonicity and convexity. A natural benchmark is established for the minimum expected length of confidence intervals at a given function in terms of an analytic quantity, the local modulus of continuity. This bound depends not only on the function but also the assumed function class. These benchmarks show that the constructed confidence intervals have near minimum expected…

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Robust Detection and Identification of Sparse Segments in Ultrahigh Dimensional Data Analysis

超高维数据中稀疏区段的稳健检测与识别

Summary Copy number variants (CNVs) are alternations of DNA of a genome that result in the cell having less or more than two copies of segments of the DNA. CNVs correspond to relatively large regions of the genome, ranging from about one kilobase to several megabases, that are deleted or duplicated. Motivated by CNV analysis based on next generation sequencing data, we consider the problem of detecting and identifying sparse short segments hidden in a long linear sequence of…

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Optimal rates of convergence for sparse covariance matrix estimation

稀疏协方差矩阵估计的最优收敛速率

This paper considers estimation of sparse covariance matrices and establishes the optimal rate of convergence under a range of matrix operator norm and Bregman divergence losses. A major focus is on the derivation of a rate sharp minimax lower bound. The problem exhibits new features that are significantly different from those that occur in the conventional nonparametric function estimation problems. Standard techniques fail to yield good results, and new tools are thus…

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Minimax and Adaptive Prediction for Functional Linear Regression

函数型线性回归的极小极大与自适应预测

This article considers minimax and adaptive prediction with functional predictors in the framework of functional linear model and reproducing kernel Hilbert space. Minimax rate of convergence for the excess prediction risk is established. It is shown that the optimal rate is determined jointly by the reproducing kernel and the covariance kernel. In particular, the alignment of these two kernels can significantly affect the difficulty of the prediction problem. In contrast,…

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Adaptive covariance matrix estimation through block thresholding

通过分块阈值化实现自适应协方差矩阵估计

Estimation of large covariance matrices has drawn considerable recent attention, and the theoretical focus so far has mainly been on developing a minimax theory over a fixed parameter space. In this paper, we consider adaptive covariance matrix estimation where the goal is to construct a single procedure which is minimax rate optimal simultaneously over each parameter space in a large collection. A fully data-driven block thresholding estimator is proposed. The estimator is…

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Optimal Detection of Heterogeneous and Heteroscedastic Mixtures

异质且异方差混合分布的最优检测

Summary The problem of detecting heterogeneous and heteroscedastic Gaussian mixtures is considered. The focus is on how the parameters of heterogeneity, heteroscedasticity and proportion of non-null component influence the difficulty of the problem. We establish an explicit detection boundary which separates the detectable region where the likelihood ratio test is shown to detect the presence of non-null effects reliably from the undetectable region where no method can do…

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Optimal estimation of the mean function based on discretely sampled functional data: Phase transition

离散采样函数数据的均值函数最优估计:相变

The problem of estimating the mean of random functions based on discretely sampled data arises naturally in functional data analysis. In this paper, we study optimal estimation of the mean function under both common and independent designs. Minimax rates of convergence are established and easily implementable rate-optimal estimators are introduced. The analysis reveals interesting and different phase transition phenomena in the two cases. Under the common design, the…

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Limiting laws of coherence of random matrices with applications to testing covariance structure and construction of compressed sensing matrices

随机矩阵相干性的极限分布及协方差检验与压缩感知应用

Testing covariance structure is of significant interest in many areas of statistical analysis and construction of compressed sensing matrices is an important problem in signal processing. Motivated by these applications, we study in this paper the limiting laws of the coherence of an n × p random matrix in the high-dimensional setting where p can be much larger than n. Both the law of large numbers and the limiting distribution are derived. We then consider testing the…

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Testing composite hypotheses, Hermite polynomials and optimal estimation of a nonsmooth functional

复合假设检验、Hermite 多项式与非光滑泛函的最优估计

A general lower bound is developed for the minimax risk when estimating an arbitrary functional. The bound is based on testing two composite hypotheses and is shown to be effective in estimating the nonsmooth functional (1/n)∑|θi| from an observation Y∼N(θ, In). This problem exhibits some features that are significantly different from those that occur in estimating conventional smooth functionals. This is a setting where standard techniques fail to yield sharp results. A…

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A reproducing kernel Hilbert space approach to functional linear regression

函数型线性回归的再生核希尔伯特空间方法

We study in this paper a smoothness regularization method for functional linear regression and provide a unified treatment for both the prediction and estimation problems. By developing a tool on simultaneous diagonalization of two positive definite kernels, we obtain shaper results on the minimax rates of convergence and show that smoothness regularized estimators achieve the optimal rates of convergence for both prediction and estimation under conditions weaker than those…

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Optimal Sparse Segment Identification With Application in Copy Number Variation Analysis

稀疏信号段的最优识别及其拷贝数变异应用

Motivated by DNA copy number variation (CNV) analysis based on high-density single nucleotide polymorphism (SNP) data, we consider the problem of detecting and identifying sparse short segments in a long one-dimensional sequence of data with additive Gaussian white noise, where the number, length and location of the segments are unknown. We present a statistical characterization of the identifiable region of a segment where it is possible to reliably separate the segment…

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Optimal rates of convergence for covariance matrix estimation

协方差矩阵估计的最优收敛速度

Covariance matrix plays a central role in multivariate statistical analysis. Significant advances have been made recently on developing both theory and methodology for estimating large covariance matrices. However, a minimax theory has yet been developed. In this paper we establish the optimal rates of convergence for estimating the covariance matrix under both the operator norm and Frobenius norm. It is shown that optimal procedures under the two norms are different and…

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