Analysis of Failure Time Data Arising From Studies With Alternating Treatment Schedules
交替治疗安排研究中的失效时间数据分析
We develop statistical methods for designing and analyzing studies in which treatments are deliberately interrupted and reinitiated, but where interest lies in making inferences about continuous treatment use. We refer to such designs as alternating designs, because subjects alternate between periods in which they are taking the treatment of interest and periods when they are not. Our goals are to determine how to estimate the distribution of time to an event if the…