Testing Against Ordered Alternatives for Censored Survival Data
删失生存数据中有序备择假设的检验
In animal carcinogenesis experiments or comparative clinical trials where the r groups correspond to increasing dosages of an agent or an increasing number of additional modalities and the primary outcome is time to a certain event (e.g., tumor occurrence, death) T, ordered alternatives of the form H1 : S1 ≤ S2 ≤ · · · ≤ Sr , where Si(t) = Pr (Ti > t) is the survival function for group are of special interest. Using the counting process formulation of the problem and…