Likelihood Ratio Test for Multi-Sample Mixture Model and Its Application to Genetic Imprinting
多样本混合模型的似然比检验及其基因印记应用
Genomic imprinting is a known aspect of the etiology of many diseases. The imprinting phenomenon depicts differential expression levels of the allele depending on its parental origin. When the parental origin is unknown, the expression level has a finite normal mixture distribution. In such applications, a random sample of expression levels consists of three subsamples according to the number of minor alleles an individual possesses, of which one is the mixture and the other…