A Bayesian Nonparametric Regression Model With Normalized Weights: A Study of Hippocampal Atrophy in Alzheimer’s Disease
带归一化权重的贝叶斯非参数回归:阿尔茨海默病海马萎缩研究
Hippocampal volume is one of the best established biomarkers for Alzheimer’s disease. However, for appropriate use in clinical trials research, the evolution of hippocampal volume needs to be well understood. Recent theoretical models propose a sigmoidal pattern for its evolution. To support this theory, the use of Bayesian nonparametric regression mixture models seems particularly suitable due to the flexibility that models of this type can achieve and the unsatisfactory…