Statistical Inference for a Two-State Markov Model of a Single Ion Channel, Incorporating Time Interval Omission
考虑短停留区间漏检的单离子通道两状态马尔可夫模型推断
SUMMARY A two-state Markov model of a single ion channel, in which successive open and closed sojourns follow negative exponential distributions with respective means μO and μC, is considered. Estimation of (μO μC) when brief sojourns in the open and closed states fail to be detected is studied. The moment estimating equations for (μO, μC) have no, one or two solutions, with two being the most common situation. The asymptotic behaviour of method-of-moments estimators of (μO,…