Harmonized estimation of subgroup-specific treatment effects in randomized trials: the use of external control data
利用外部对照数据协调随机试验的亚组处理效应估计
Abstract Subgroup analyses of randomized controlled trials (RCTs) constitute an important component of the drug development process in precision medicine. In particular, subgroup analyses of early-stage trials often influence the design and eligibility criteria of subsequent confirmatory trials and ultimately influence which subpopulations will receive the treatment after regulatory approval. However, subgroup analyses are often complicated by small sample sizes, which leads…