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二项临床试验的序贯分析AI 解读

We examine results produced by a new likelihood stopping rule for terminating clinical trials, designed to choose the better of two competing dichotomous treatmente, or to decide that they are equal. A method for adaptive assignment is also discussed, for the purpose of reducing the number of tests with the poorer treatment. A comparison of results with several alternative designs given in the literature shows that the proposed design either gives substantial improvement…

二项结局临床试验的序贯分析AI 解读

We examine results produced by a new likelihood stopping rule for terminating clinical trials, designed to choose the better of two competing dichotomous treatmente, or to decide that they are equal. A method for adaptive assignment is also discussed, for the purpose of reducing the number of tests with the poorer treatment. A comparison of results with several alternative designs given in the literature shows that the proposed design either gives substantial improvement…