Bayesian Random Segmentation Models to Identify Shared Copy Number Aberrations for Array CGH Data
识别阵列 CGH 数据共享拷贝数异常的贝叶斯随机分段模型
Array-based comparative genomic hybridization (aCGH) is a high-resolution high-throughput technique for studying the genetic basis of cancer. The resulting data consists of log fluorescence ratios as a function of the genomic DNA location and provides a cytogenetic representation of the relative DNA copy number variation. Analysis of such data typically involves estimation of the underlying copy number state at each location and segmenting regions of DNA with similar copy…