Exact Tests for in Situ Hybridization Experiments
原位杂交实验的精确检验
Radioactively labeled gene probes are observed as “grains” that identify specific sites of hybridization within chromosomes, suggesting potential sites for a target gene. Based on the resolution of the assay, chromosomes are subdivided into bins of approximately equal length, and the number of grains in each bin is tallied. To distinguish true hybridization sites from nonspecific binding, we propose a test statistic, Z max, based on the number of grains in any two adjacent…