Adaptive bootstrap tests for composite null hypotheses in the mediation pathway analysis
中介路径分析中复合原假设的自适应 Bootstrap 检验
Abstract Mediation analysis aims to assess if, and how, a certain exposure influences an outcome of interest through intermediate variables. This problem has recently gained a surge of attention due to the tremendous need for such analyses in scientific fields. Testing for the mediation effect (ME) is greatly challenged by the fact that the underlying null hypothesis (i.e. the absence of MEs) is composite. Most existing mediation tests are overly conservative and thus…