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Modelling positive and unlabelled data with a generalized additive density ratio model

用广义加性密度比模型处理正例与未标记数据

Abstract This paper focuses on learning from positive and unlabelled (PU) data, where only some positives are labelled and the rest are mixed with negatives. Classical exponential tilting models guarantee identifiability by imposing a linear structure, but they can be severely misspecified when the true relationships are nonlinear. We propose a generalized additive density-ratio framework that retains identifiability while allowing nonlinear and feature-specific effects. The…

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Maximum Binomial Likelihood Method for Multivariate Mixture Data

多元混合数据的最大二项似然方法

Multivariate mixture data analysis presents numerous challenges and constitutes a vital area of interest in the fields of statistics and data science. Research into multivariate mixture structures holds relevance across diverse application domains and plays a pivotal role in the advancement of artificial intelligence and machine learning. In this article, we focus on nonparametric estimation techniques for multivariate mixture data. Specifically, we assume a known number of…

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Positive and Unlabeled Data: Model, Estimation, Inference, and Classification

正例与未标记数据:模型、估计、推断与分类

This study introduces a new approach to addressing the positive and unlabeled (PU) data through the double exponential tilting model (DETM) under a transfer learning framework. Traditional methods often fall short because they only apply to the common distributions (CD) PU data (also known as the selected completely at random PU data), where the labeled positive and unlabeled positive data are assumed to be from the same distribution. In contrast, our DETM’s dual structure…

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Maximum pairwise-rank-likelihood-based inference for the semiparametric transformation model

半参数变换模型中基于最大成对秩似然的推断

In this paper, we study the linear transformation model in a general setup. This model includes many important and popular models in statistics and econometrics as special cases. Although it has been studied for many years, the methods in the literature are based on kernel-smoothing techniques or make use of only the ranks of the responses in the estimation of the parametric components. The former approach needs a tuning parameter, which is not easily optimally specified in…

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Semi-parametric inference on Gini indices of two semi-continuous populations under density ratio models

密度比模型下两个半连续总体基尼指数的半参数推断

Summary The Gini index is a popular inequality measure with many applications in social and economic studies. This paper studies semi-parametric inference on the Gini indices of two semi-continuous populations. We characterise the distribution of each semi-continuous population by a mixture of a discrete point mass at zero and a continuous skewed positive component. A semi-parametric density ratio model is then employed to link the positive components of the two…

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Doubly Robust Inference With Nonprobability Survey Samples

非概率调查样本的双重稳健推断

We establish a general framework for statistical inferences with nonprobability survey samples when relevant auxiliary information is available from a probability survey sample. We develop a rigorous procedure for estimating the propensity scores for units in the nonprobability sample, and construct doubly robust estimators for the finite population mean. Variance estimation is discussed under the proposed framework. Results from simulation studies show the robustness and…

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Full Likelihood Inference for Abundance from Continuous Time Capture–Recapture Data

连续时间捕获—再捕获数据中总体数量的全似然推断

Summary Capture–recapture experiments are widely used cost-effective sampling techniques for estimating population sizes or abundances in biology, ecology, demography, epidemiology and reliability studies. For continuous time capture–recapture data, existing estimation methods are based on conditional likelihoods and an inverse weighting estimating equation. The corresponding Wald-type confidence intervals for the abundance may have severe undercoverage, and their lower…

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Semiparametric Inference in a Genetic Mixture Model

遗传混合模型中的半参数推断

In genetic backcross studies, data are often collected from complex mixtures of distributions with known mixing proportions. Previous approaches to the inference of these genetic mixture models involve parameterizing the component distributions. However, model misspecification of any form is expected to have detrimental effects. We propose a semiparametric likelihood method for genetic mixture models: the empirical likelihood under the exponential tilting model assumption,…

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Density estimation in the two-sample problem with likelihood ratio ordering

似然比有序约束下的两样本密度估计

In this paper, we propose a method for estimating the probability density functions in a two-sample problem where the ratio of the densities is monotone. This problem has been widely identified in the literature, but effective solution methods, in which the estimates should be probability densities and the corresponding density ratio should inherit monotonicity, are unavailable. If these conditions are not satisfied, the applications of the resultant density estimates might…

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Using a Monotonic Density Ratio Model to Find the Asymptotically Optimal Combination of Multiple Diagnostic Tests

利用单调密度比模型寻找多项诊断测试的渐近最优组合

With the advent of new technology, new biomarker studies have become essential in cancer research. To achieve optimal sensitivity and specificity, one needs to combine different diagnostic tests. The celebrated Neyman–Pearson lemma enables us to use the density ratio to optimally combine different diagnostic tests. In this article, we propose a semiparametric model by directly modeling the density ratio between the diseased and nondiseased population as an unspecified…

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Spatial Shrinkage Estimation of Diffusion Tensors on Diffusion-Weighted Imaging Data

扩散加权成像数据中扩散张量的空间收缩估计

Diffusion tensor imaging (DTI), based on the diffusion-weighted imaging (DWI) data acquired from magnetic resonance experiments, has been widely used to analyze the physical structure of white-matter fibers in the human brain in vivo. The raw DWI data, however, carry noise; this contaminates the diffusion tensor (DT) estimates and introduces systematic bias into the induced eigenvalues. These bias components affect the effectiveness of fiber-tracking algorithms. In this…

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Inference on the Order of a Normal Mixture

正态混合模型成分数的推断

Finite normal mixture models are used in a wide range of applications. Hypothesis testing on the order of the normal mixture is an important yet unsolved problem. Existing procedures often lack a rigorous theoretical foundation. Many are also hard to implement numerically. In this article, we develop a new method to fill the void in this important area. An effective expectation-maximization (EM) test is invented for testing the null hypothesis of arbitrary order m 0 under a…

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A New Nuisance-Parameter Elimination Method With Application to the Unordered Homologous Chromosome Pairs Problem

一种新的干扰参数消除方法及其在无序同源染色体对问题中的应用

Motivated by applications of the case–control model or exponential tilting model in the unordered homologous chromosome pairs problem in genetic studies and in the interim analysis in double-blinded clinical trials, we develop a new nuisance-parameter elimination method based on the empirical Shannon’s mutual information. The asymptotic behaviors of the maximum empirical Shannon’s mutual information estimation and the empirical Shannon’s mutual information test are similar…

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Robustness of Design in Dose–Response Studies

剂量—反应研究中实验设计的稳健性

Summary We construct experimental designs for dose–response studies. The designs are robust against possibly misspecified link functions; for this they minimize the maximum mean-squared error of the estimated dose required to attain a response in 100p% of the target population. Here p might be one particular value—p = 0.5 corresponds to ED50-estimation—or it might range over an interval of values of interest. The maximum of the mean-squared error is evaluated over a…

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Testing the Order of a Finite Mixture

有限混合模型的阶数检验

The order is an important parameter in applications of finite mixture models. Yet designing a valid and easy-to-use statistical test for the order is challenging. To date, most results on hypothesis tests have focused on homogeneity, a special case where the null model has order 1. In this work, we designed an EM test for the general problem of testing the null hypothesis of order m0 versus an alternative hypothesis of order larger than m0. For any positive integer m0, the…

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Hypothesis test for normal mixture models: The EM approach

正态混合模型的假设检验:EM 方法

Normal mixture distributions are arguably the most important mixture models, and also the most technically challenging. The likelihood function of the normal mixture model is unbounded based on a set of random samples, unless an artificial bound is placed on its component variance parameter. Moreover, the model is not strongly identifiable so it is hard to differentiate between over dispersion caused by the presence of a mixture and that caused by a large variance, and it…

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