Selecting One of Two Treatments When the Responses are Dichotomous
二元治疗反应下的两种疗法选择
A decision theoretic approach to the design of a clinical trial is considered for the situation in which a total of N patients with a disease receive one of two treatments and the responses to the treatments are dichotomous. Two costs are considered: The cost of treating a patient with the inferior treatment and the cost of conducting the trial. Minimax and Bayes procedures are used to determine the optimum size of a fixed sample trial. Bayes solutions for the optimum sample…