Semiparametric analysis of complex polygenic gene-environment interactions in case-control studies
病例对照研究中复杂多基因与环境交互作用的半参数分析
Many methods have recently been proposed for efficient analysis of case-control studies of gene-environment interactions using a retrospective likelihood framework that exploits the natural assumption of gene-environment independence in the underlying population. However, for polygenic modelling of gene-environment interactions, which is a topic of increasing scientific interest, applications of retrospective methods have been limited due to a requirement in the literature…