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利用纵向CD4 T细胞数量研究HIV感染进展的层级贝叶斯模型AI 解读

Taking the absolute number of CD4 T-cells as a marker of disease progression for persons infected with the human immunodeficiency virus (HIV), we model longitudinal series of such counts for a sample of 327 subjects in the San Francisco Men's Health Study (Waves 1–8, excluding zidovudine cases). We conduct a fully Bayesian analysis of these data. We employ individual level nonlinear models incorporating such critical features as incomplete and unbalanced data, population…

随机效应模型的正态性评估AI 解读

When one uses the unbalanced, mixed linear model $\mathbf{y}_i = \mathbf{X}_i\mathbf{\alpha} + \mathbf{Z}_i\mathbf{\beta}_i + \varepsilon_i, i = 1, \cdots, n$ to analyze data from longitudinal experiments with continuous outcomes, it is customary to assume $\varepsilon_i \sim_{\operatorname{ind}} \mathscr{N}(\mathbf{0}, \sigma^2\mathbf{I}_i)$ independent of $\mathbf{\beta}_i \sim_{\operatorname{iid}} \mathscr{N}(\mathbf{0,\Delta})$, where $\sigma^2$ and the elements of an…

协方差结构对平衡随机参数增长曲线模型方差估计的影响AI 解读

Intuition suggests that altering the covariance structure of a parametric model for repeated-measures data alters the variances of the model's estimated mean parameters. The purpose of this article is to sharpen such intuition for a family of growth-curve models with differing numbers of random effects for the individual sampling units and with a fixed structure on the mean. For every member of this family, the maximum likelihood (ML) estimator of the fixed effects is…

重复测量的最大似然计算：EM 算法的应用AI 解读

The purpose of this article is to consider the use of the EM algorithm (Dempster, Laird, and Rubin 1977) for both maximum likelihood (ML) and restricted maximum likelihood (REML) estimation in a general repeated measures setting using a multivariate normal data model with linear mean and covariance structure (Anderson 1973). Several models and methods of analysis have been proposed in recent years for repeated measures data; Ware (1985) presented an overview. Because the EM…