Some Statistical Strategies for DAE-seq Data Analysis: Variable Selection and Modeling Dependencies Among Observations
DAE-seq 数据分析:变量选择与观测依赖建模
In DAE (DNA After Enrichment)-seq experiments, genomic regions related with certain biological processes are enriched/isolated by an assay and are then sequenced on a high-throughput sequencing platform to determine their genomic positions. Statistical analysis of DAE-seq data aims to detect genomic regions with significant aggregations of isolated DNA fragments ("enriched regions") versus all the other regions ("background"). However, many confounding factors may influence…