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通过知识驱动的在线多模态自动表型系统降低电子健康记录研究门槛AI 解读

Electronic health records (EHRs) hold great promise for translational research but remain difficult to use at scale because diagnostic codes are noisy, disease-relevant features are hard to identify, high-quality labels are limited and patient-level data sharing is often restricted. We introduce Knowledge-driven Online Multimodal Automated Phenotyping (KOMAP), a unified system for automated, privacy-preserving EHR phenotyping using summary statistics. The system is organized…

基于核岭回归的条件平均处理效应迁移学习AI 解读

The proliferation of data has sparked significant interest in leveraging findings from one study to estimate treatment effects in a different target population without direct outcome observations. However, the transfer learning process is frequently hindered by substantial covariate shift and limited overlap between (i) the source and target populations, as well as (ii) the treatment and control groups within the source. We propose a novel method for overlap-adaptive…

半监督三重稳健归纳迁移学习AI 解读

In this work, we propose a Semi-supervised Triply Robust Inductive transFer LEarning (STRIFLE) approach, which integrates heterogeneous data from a label-rich source population and a label-scarce target population and uses a large amount of unlabeled data simultaneously to improve the learning accuracy in the target population. Specifically, we consider a high dimensional covariate shift setting and employ two nuisance models, a density ratio model and an imputation model,…

高维特征下的双重稳健增广模型准确度迁移推断AI 解读

Transfer learning is crucial for training models that generalize to unlabeled target populations using labeled source data, especially in real-world studies where label scarcity and covariate shift are common. While most research focuses on model estimation, there is limited literature on transfer inference for model accuracy despite its importance. We introduce a novel Doubly Robust Augmented Model Accuracy Transfer Inferen Ce (DRAMATIC) method for point and interval…

Maxway CRT：提高 model-X 推断的稳健性AI 解读

Abstract The model-X conditional randomisation test (CRT) is a flexible and powerful testing procedure for testing the hypothesis X⫫Y∣Z. However, it requires perfect knowledge of X∣Z and may lose its validity when there is an error in modelling X∣Z. This problem is even more severe when Z is of high dimensionality. In response to this, we propose the Maxway CRT, which learns the distribution of Y∣Z and uses it to calibrate the resampling distribution of X to gain robustness…

识别他汀使用相关二型糖尿病风险最高的亚组：电子健康记录证据AI 解读

There have been increased concerns that the use of statins, one of the most commonly prescribed drugs for treating coronary artery disease, is potentially associated with the increased risk of new-onset Type II diabetes (T2D). Nevertheless, to date, there is no robust evidence supporting as to whether and what kind of populations are indeed vulnerable for developing T2D after taking statins. In this case study, leveraging the biobank and electronic health record data in the…

保护个体数据的高维异质研究整合回归AI 解读

Evidence-based decision making often relies on meta-analyzing multiple studies, which enables more precise estimation and investigation of generalizability. Integrative analysis of multiple heterogeneous studies is, however, highly challenging in the ultra high-dimensional setting. The challenge is even more pronounced when the individual-level data cannot be shared across studies, known as DataSHIELD contraint. Under sparse regression models that are assumed to be similar…

分层抽样下半监督预测规则的高效评估AI 解读

Abstract In many contemporary applications, large amounts of unlabelled data are readily available while labelled examples are limited. There has been substantial interest in semi-supervised learning (SSL) which aims to leverage unlabelled data to improve estimation or prediction. However, current SSL literature focuses primarily on settings where labelled data are selected uniformly at random from the population of interest. Stratified sampling, while posing additional…

通过蒸馏实现快速且有力的条件随机化检验AI 解读

Summary We consider the problem of conditional independence testing: given a response $Y$ and covariates $(X,Z)$, we test the null hypothesis that $Y {\perp\!\!\!\perp} X \mid Z$. The conditional randomization test was recently proposed as a way to use distributional information about $X\mid Z$ to exactly and nonasymptotically control Type-I error using any test statistic in any dimensionality without assuming anything about $Y\mid (X,Z)$. This flexibility, in principle,…