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聚类干扰下随机政策效应的高效非参数估计AI 解读

Interference occurs when a unit's treatment (or exposure) affects another unit's outcome. In some settings, units may be grouped into clusters such that it is reasonable to assume that interference, if present, only occurs between individuals in the same cluster, i.e., there is clustered interference. Various causal estimands have been proposed to quantify treatment effects under clustered interference from observational data, but these estimands either entail treatment…

未知干扰下的平均处理效应AI 解读

We investigate large-sample properties of treatment effect estimators under unknown interference in randomized experiments. The inferential target is a generalization of the average treatment effect estimand that marginalizes over potential spillover effects. We show that estimators commonly used to estimate treatment effects under no interference are consistent for the generalized estimand for several common experimental designs under limited but otherwise arbitrary and…

存在干扰时因果效应的大样本随机化推断AI 解读

Recently, increasing attention has focused on making causal inference when interference is possible. In the presence of interference, treatment may have several types of effects. In this paper, we consider inference about such effects when the population consists of groups of individuals where interference is possible within groups but not between groups. A two stage randomization design is assumed where in the first stage groups are randomized to different treatment…

随机临床试验中依方案生存终点疗效的敏感性分析AI 解读

Assessing per-protocol treatment effcacy on a time-to-event endpoint is a common objective of randomized clinical trials. The typical analysis uses the same method employed for the intention-to-treat analysis (e.g., standard survival analysis) applied to the subgroup meeting protocol adherence criteria. However, due to potential post-randomization selection bias, this analysis may mislead about treatment efficacy. Moreover, while there is extensive literature on methods for…

主分层内基于随机化的推断AI 解读

In randomized studies, treatment comparisons conditional on intermediate post-randomization outcomes using standard analytic methods do not have a causal interpretation. An alternate approach entails treatment comparisons within principal strata defined by the potential outcomes for the intermediate outcome that would be observed under each treatment assignment. In this paper, we develop methods for randomization-based inference within principal strata. The proposed methods…

区间删失与左截断下的非参数极大似然估计AI 解读

Summary A graph theoretical approach is employed to describe the support set of the nonparametric maximum likelihood estimator for the cumulative distribution function given interval-censored and left-truncated data. A necessary and sufficient condition for the existence of a nonparametric maximum likelihood estimator is then derived. Two previously analysed data sets are revisited.