Parametric and Nonparametric Methods for Understanding the Relationship Between Carcinogen-Induced DNA Adduct Levels in Distal and Proximal Regions of the Colon
结肠远端与近端致癌物诱导 DNA 加合物水平关系的参数与非参数方法
An important problem in studying the etiology of colon cancer is understanding the relationship between DNA adduct levels (broadly, DNA damage) in cells within colonic crypts in distal and proximal parts of the colon, following treatment with a carcinogen and different types of diet. In particular, it is important to understand whether rats who have elevated adduct levels in particular positions in distal region crypts also have elevated levels in the same positions of the…