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Nonparametric Tests of Treatment Effect Homogeneity for Policy-Makers

面向政策制定者的处理效应同质性非参数检验

Recent work has focused on nonparametric estimation of conditional treatment effects, but inference has remained relatively unexplored. We propose a class of nonparametric tests for both quantitative and qualitative treatment effect heterogeneity. The tests can incorporate a variety of structured assumptions on the conditional average treatment effect, allow for both continuous and discrete covariates, and do not require sample splitting to obtain a tractable asymptotic null…

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Improved Bounds and Inference on Optimal Regimes

最优治疗规则的改进界与推断

Point identification of causal effects requires strong assumptions that are unreasonable in many practical settings. However, informative bounds on these effects can often be derived under plausible assumptions. Even when these bounds are wide or cover null effects, they can guide practical decisions based on formal decision theoretic criteria. Here we derive new results on optimal treatment regimes in settings where the effect of interest is bounded. These results are…

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Conditional Separable Effects

条件可分离效应

Researchers are often interested in treatment effects on outcomes that are only defined conditional on posttreatment events. For example, in a study of the effect of different cancer treatments on quality of life at end of follow-up, the quality of life of individuals who die during the study is undefined. In these settings, naive contrasts of outcomes conditional on posttreatment events are not average causal effects, even in randomized experiments. Therefore, the effect in…

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Mats J Stensrud and Aaron L. Sarvet’s Contribution to the Discussion of ‘Assumption-Lean Inference for Generalised Linear Model Parameters’ by Vansteelandt and Dukes

Stensrud 与 Sarvet 对《广义线性模型参数的弱假设推断》的讨论

We congratulate Vansteelandt and Dukes (V & D) with their innovative and interesting article. Here we further explore the interpretation of V & D’s main effects estimand. An algorithm for causal inference. There has been tremendous progress in causal inference by approaching causal queries in the following way (Hernan & Robins, 2020; Richardson & Robins, 2013; Robins, 1986): Choose a causal target: an estimand that corresponds to a scientific question of interest (usually a…

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Separable Effects for Causal Inference in the Presence of Competing Events

存在竞争事件时用于因果推断的可分离效应

In time-to-event settings, the presence of competing events complicates the definition of causal effects. Here we propose the new separable effects to study the causal effect of a treatment on an event of interest. The separable direct effect is the treatment effect on the event of interest not mediated by its effect on the competing event. The separable indirect effect is the treatment effect on the event of interest only through its effect on the competing event. Similar…

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