Time-Dependent Predictive Values of Prognostic Biomarkers With Failure Time Outcome
生存结局下预后生物标志物的时间依赖预测值
In a prospective cohort study, information on clinical parameters, tests and molecular markers is often collected. Such information is useful to predict patient prognosis and to select patients for targeted therapy. We propose a new graphical approach, the positive predictive value (PPV) curve, to quantify the predictive accuracy of prognostic markers measured on a continuous scale with censored failure time outcome. The proposed method highlights the need to consider both…