Multivariate Analysis of Longitudinal Ordinal Data With Mixed Effects Models, With Application to Clinical Outcomes in Osteoarthritis
纵向有序数据的多元混合效应分析及骨关节炎临床应用
Our objective was to evaluate the efficacy of robenacoxib in osteoarthritic dogs using four ordinal responses measured repeatedly over time. We propose a multivariate probit mixed effects model to describe the joint evolution of endpoints and to evidence the intrinsic correlations between responses that are not due to treatment effect. Maximum likelihood computation is intractable within reasonable time frames. We therefore use a pairwise modeling approach in combination…