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函数索引加权对数秩统计量的多用途检验AI 解读

Two-sample weighted log-rank statistics are used in the presence of right censoring to test whether failure times from two populations have different survival distributions. Kosorok has showed that large families of these statistics form stochastic processes indexed by weight functions, and that these function-indexed statistics can be used to construct versatile test procedures simultaneously sensitive to a wide array of both ordered hazards and stochastic ordering…

连续时间中的纵向有序响应数据分析AI 解读

A simple Markov model is developed for assessing the predictive effect of time-dependent covariates on an intermittently observed ordinal response in continuous time. This is accomplished by reparameterizing an ergodic intensity matrix in terms of its equilibrium distribution and a parametrically independent component that assesses the rate of movement between ordinal categories. The effect of covariates on the equilibrium distribution can then be modeled using any link…

连续时间纵向有序响应数据分析AI 解读

A simple Markov model is developed for assessing the predictive effect of time-dependent covariates on an intermittently observed ordinal response in continuous time. This is accomplished by reparameterizing an ergodic intensity matrix in terms of its equilibrium distribution and a parametrically independent component that assesses the rate of movement between ordinal categories. The effect of covariates on the equilibrium distribution can then be modeled using any link…

利用替代失效时间数据提高临床试验的成本效益AI 解读

In clinical trials with failure time, outcomes, the cost of follow-up for the endpoint of primary interest is sometimes expensive. In many of these settings, one or more secondary or surrogate failure time outcomes are also available which either occur much earlier or are much less expensive to follow than the primary outcome. This paper presents a method for using these secondary outcomes to increase the power of detecting a treatment effect on the primary outcome only,…

利用替代失效时间数据提高临床试验的成本效益AI 解读

In clinical trials with failure time, outcomes, the cost of follow-up for the endpoint of primary interest is sometimes expensive. In many of these settings, one or more secondary or surrogate failure time outcomes are also available which either occur much earlier or are much less expensive to follow than the primary outcome. This paper presents a method for using these secondary outcomes to increase the power of detecting a treatment effect on the primary outcome only,…