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BAP：多药物多剂量试验的贝叶斯生物标志物辅助平台设计AI 解读

Assessing the long-term benefits of new treatments can be expensive and time-consuming, particularly in disease areas with unmet medical needs. While platform trials enable the evaluation of multiple interventions simultaneously, they currently cannot assess studies involving multiple agents and doses or utilize longitudinal biomarkers in decision-making. We propose a Bayesian biomarker-assisted platform design that offers a unified framework for evaluating multiple…

复杂区域上分位数空间变系数模型的估计与推断AI 解读

This article presents a flexible quantile spatially varying coefficient model (QSVCM) for the regression analysis of spatial data. The proposed model enables researchers to assess the dependence of conditional quantiles of the response variable on covariates while accounting for spatial nonstationarity. Our approach facilitates learning and interpreting heterogeneity in spatial data distributed over complex or irregular domains. We introduce a quantile regression method that…

空间变系数广义部分线性模型的分布式异质性学习AI 解读

Spatial heterogeneity is of great importance in social, economic, and environmental science studies. The spatially varying coefficient model is a popular and effective spatial regression technique to address spatial heterogeneity. However, accounting for heterogeneity comes at the cost of reducing model parsimony. To balance flexibility and parsimony, this article develops a class of generalized partially linear spatially varying coefficient models which allow the inclusion…

超高维图像对标量回归中的稀疏学习与结构识别AI 解读

This article considers high-dimensional image-on-scalar regression, where the spatial heterogeneity of covariate effects on imaging responses is investigated via a flexible partially linear spatially varying coefficient model. To tackle the challenges of spatial smoothing over the imaging response’s complex domain consisting of regions of interest, we approximate the spatially varying coefficient functions via bivariate spline functions over triangulation. We first study…

广义地理加性模型的估计与推断AI 解读

In many application areas, data are collected on a count or binary response with spatial covariate information. In this article, we introduce a new class of generalized geoadditive models (GGAMs) for spatial data distributed over complex domains. Through a link function, the proposed GGAM assumes that the mean of the discrete response variable depends on additive univariate functions of explanatory variables and a bivariate function to adjust for the spatial effect. We…

协变量维数增长时相关数据的广义可加部分线性模型估计与选择AI 解读

We propose generalized additive partial linear models for complex data which allow one to capture nonlinear patterns of some covariates, in the presence of linear components. The proposed method improves estimation efficiency and increases statistical power for correlated data through incorporating the correlation information. A unique feature of the proposed method is its capability of handling model selection in cases where it is difficult to specify the likelihood…

参数条件分布的积分条件矩检验AI 解读

In this paper we propose consistent integrated conditional moment tests for the validity of parametric conditional distribution models, based on the integrated squared difference between the empirical characteristic function of the actual data and the characteristic function implied by the model. To avoid numerical evaluation of the conditional characteristic function of the model distribution, a simulated integrated conditional moment test is proposed. As an empirical…

广义可加部分线性模型的估计与变量选择AI 解读

We study generalized additive partial linear models, proposing the use of polynomial spline smoothing for estimation of nonparametric functions, and deriving quasi-likelihood based estimators for the linear parameters. We establish asymptotic normality for the estimators of the parametric components. The procedure avoids solving large systems of equations as in kernel-based procedures and thus results in gains in computational simplicity. We further develop a class of…

非线性加性自回归模型的样条回拟合核平滑AI 解读

Application of nonparametric and semiparametric regression techniques to high-dimensional time series data has been hampered due to the lack of effective tools to address the “curse of dimensionality.” Under rather weak conditions, we propose spline-backfitted kernel estimators of the component functions for the nonlinear additive time series data that are both computationally expedient so they are usable for analyzing very high-dimensional time series, and theoretically…