Crossed Random Effect Models for Multiple Outcomes in a Study of Teratogenesis
致畸研究中多结局的交叉随机效应模型
Human teratogens often manifest themselves through a broad spectrum of adverse effects. Although often not serious when considered individually, such outcomes taken together may represent a syndrome that can lead to serious developmental problems. Accordingly, studies that investigate the effect of human teratogens on fetal development typically record the presence or absence of a multitude of abnormalities, resulting in the data of multivariate binary form for each infant.…