Markov chains for Monte Carlo tests of genetic equilibrium in multidimensional contingency tables
多维列联表遗传平衡蒙特卡洛检验的马尔可夫链
Hardy-Weinberg equilibrium and linkage equilibrium are fundamental concepts in population genetics. In practice, testing linkage equilibrium in haplotype data is equivalent to testing independence in a large, sparse, multidimensional contingency table. Testing Hardy-Weinberg and linkage equilibrium simultaneously on multilocus genotype data introduces the additional complications of missing information and symmetry constraints on marginal probabilities. To avoid unreliable…