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Abstract Double cross-fit doubly robust (DCDR) estimators, which train nuisance function estimators on separate samples, are effective new estimators for causal functionals. We establish several novel theoretical results for them, building on recent work. We provide a structure-agnostic error analysis, which holds with generic nuisance functions and estimators. Then, we propose n-consistent DCDR estimators with undersmoothed local polynomial regression and k-Nearest…

利用代理控制结局的数据整合后推断AI 解读

Summary Data integration methods aim to extract low-dimensional embeddings from high-dimensional outcomes to remove unwanted variation, such as batch effects and unmeasured covariates, across heterogeneous datasets. However, multiple hypothesis testing after integration can be biased due to data-dependent processes. We introduce a robust post-integrated inference method that accounts for latent heterogeneity by leveraging control outcomes. Using causal interpretations, we…

多重异质结果下基因组数据的因果推断AI 解读

With the evolution of single-cell RNA sequencing techniques into a standard approach in genomics, it has become possible to conduct cohort-level causal inferences based on single-cell-level measurements. However, the individual gene expression levels of interest are not directly observable; instead, only repeated proxy measurements from each individual's cells are available, providing a derived outcome to estimate the underlying outcome for each of many genes. In this paper,…

含干预的半机制流行病模型：频率学派推断AI 解读

Abstract The effect of public health interventions on an epidemic are often estimated by adding the intervention to epidemic models. During the Covid-19 epidemic, numerous papers used such methods for making scenario predictions. The majority of these papers use Bayesian methods to estimate the parameters of the model. In this article, we show how to use frequentist methods for estimating these effects which avoids having to specify prior distributions. We also use…

异质性因果效应估计的极小极大收敛率AI 解读

Estimation of heterogeneous causal effects - i.e., how effects of policies and treatments vary across subjects - is a fundamental task in causal inference. Many methods for estimating conditional average treatment effects (CATEs) have been proposed in recent years, but questions surrounding optimality have remained largely unanswered. In particular, a minimax theory of optimality has yet to be developed, with the minimax rate of convergence and construction of rate-optimal…

非参数众数回归AI 解读

Modal regression estimates the local modes of the distribution of $Y$ given $X=x$, instead of the mean, as in the usual regression sense, and can hence reveal important structure missed by usual regression methods. We study a simple nonparametric method for modal regression, based on a kernel density estimate (KDE) of the joint distribution of $Y$ and $X$. We derive asymptotic error bounds for this method, and propose techniques for constructing confidence sets and…

逮捕率的层级贝叶斯分析AI 解读

A Bayesian hierarchical model provides the basis for calibrating the crimes avoided by incarceration of individuals convicted of drug offenses compared to those convicted of nondrug offenses. Two methods for constructing reference priors for hierarchical models both lead to the same prior in the final model. We use Markov chain Monte Carlo methods to fit the model to data from a random sample of past arrest records of all felons convicted of drug trafficking, drug…