Segregation analysis of human pedigrees using estimating equations
基于估计方程的人类家系遗传分离分析
Studies in genetic epidemiology are generally required to collect phenotypes on subjects from human pedigrees that consist of blood relatives and their spouses. One of the main objectives in analyzing pedigree data is to study the segregation of underlying genes that may predispose certain phenotypes and thus cause phenotypic aggregation within pedigrees. Most classical segregation methods are maximum likelihood-based under highly specified distributional assumptions for…