Sparse Simultaneous Signal Detection for Identifying Genetically Controlled Disease Genes
用于识别遗传调控疾病基因的稀疏同时信号检测
Genome-wide association studies (GWAS) and differential expression analyses have had limited success in finding genes that cause complex diseases such as heart failure (HF), a leading cause of death in the United States. This article proposes a new statistical approach that integrates GWAS and expression quantitative trait loci (eQTL) data to identify important HF genes. For such genes, genetic variations that perturb its expression are also likely to influence disease risk.…