A Note on Nonparametric Estimation of the Effective Dose in Quantal Bioassay
二元反应生物测定中有效剂量的非参数估计札记
For the common binary response model, we propose a direct method for the nonparametric estimation of the effective dose level. The estimator is obtained by the composition of a nonparametric estimate of the quantile response curve and a classical density estimate. The new method yields a simple and reliable monotone estimate of the effective dose-level curve α → EDα and is appealing to users of conventional smoothing methods as kernel estimators, local polynomials, series…