A Model Selection Approach for the Identification of Quantitative Trait Loci in Experimental Crosses
实验杂交中数量性状基因座识别的模型选择方法
Summary We consider the problem of identifying the genetic loci (called quantitative trait loci (QTLs)) contributing to variation in a quantitative trait, with data on an experimental cross. A large number of different statistical approaches to this problem have been described; most make use of multiple tests of hypotheses, and many consider models allowing only a single QTL. We feel that the problem is best viewed as one of model selection. We discuss the use of model…