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非线性混合效应模型中时变协变量测量误差的两步处理：IGF-I药代动力学应用AI 解读

The usual approach to the analysis of population pharmacokinetic studies is to represent the concentration-time data by a nonlinear mixed-effects model. Primary objectives are to characterize the pattern of drug disposition in the population and to identify individual-specific covariates associated with pharmacokinetic behavior. We consider data from a study of insulin-like growth factor I (IGF-I) administered by intravenous infusion to patients with severe head trauma.…

非线性混合效应模型中时变协变量测量误差的两步法：IGF-I 药代动力学应用AI 解读

The usual approach to the analysis of population pharmacokinetic studies is to represent the concentration-time data by a nonlinear mixed-effects model. Primary objectives are to characterize the pattern of drug disposition in the population and to identify individual-specific covariates associated with pharmacokinetic behavior. We consider data from a study of insulin-like growth factor I (IGF-I) administered by intravenous infusion to patients with severe head trauma.…