Optimal Designs for Dose-Finding Studies
剂量探索研究的最优设计
Understanding and properly characterizing the dose–response relationship is a fundamental step in the investigation of a new compound, be it a herbicide or fertilizer, a molecular entity, an environmental toxin, or an industrial chemical. In this article we investigate the problem of deriving efficient designs for the estimation of target doses in the context of clinical dose finding. We propose methods to determine the appropriate number and actual levels of the doses to be…