A Bayesian Approach to Multistate Hidden Markov Models: Application to Dementia Progression
多状态隐马尔可夫模型的贝叶斯方法:痴呆进展应用
People are living longer than ever before, and with this arises new complications and challenges for humanity. Among the most pressing of these challenges is of understanding the role of aging in the development of dementia. This article is motivated by the Mayo Clinic Study of Aging data for 4742 subjects since 2004, and how it can be used to draw inference on the role of aging in the development of dementia. We construct a hidden Markov model (HMM) to represent progression…