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配对研究与协变量测量误差中的正交局部辅助估计函数AI 解读

Summary We propose an estimating function method for two related applications, matched pair studies and studies with errors in covariates under a functional model, where a mismeasured unknown scalar covariate is treated as a fixed nuisance parameter. Our method addresses the severe inferential problem that is posed by an abundance of nuisance parameters in these two applications. We propose orthogonal locally ancillary estimating functions for these two applications that…

稀疏聚类数据的复合条件似然AI 解读

Summary Sparse clustered data arise in finely stratified genetic and epidemiologic studies and pose at least two challenges to inference. First, it is difficult to model and interpret the full joint probability of dependent discrete data, which limits the utility of full likelihood methods. Second, standard methods for clustered data, such as pairwise likelihood and the generalized estimating function approach, are unsuitable when the data are sparse owing to the presence of…

Summary When measurement error is present in covariates, it is well known that naïvely fitting a generalized linear model results in inconsistent inferences. Several methods have been proposed to adjust for measurement error without making undue distributional assumptions about the unobserved true covariates. Stefanski and Carroll focused on an unbiased estimating function rather than a likelihood approach. Their estimating function, known as the conditional score, exists…

一般估计函数的近似似然比AI 解读

The method of estimating functions (Godambe, 1991) is commonly used when one desires to conduct inference about some parameters of interest but the full distribution of the observations is unknown. However, this approach may have limited utility, due to multiple roots for the estimating function, a poorly behaved Wald test, or lack of a goodness-of-fit test. This paper presents approximate likelihood ratios that can be used along with estimating functions when any of these…

一般估计函数的近似似然比AI 解读

The method of estimating functions (Godambe, 1991) is commonly used when one desires to conduct inference about some parameters of interest but the full distribution of the observations is unknown. However, this approach may have limited utility, due to multiple roots for the estimating function, a poorly behaved Wald test, or lack of a goodness-of-fit test. This paper presents approximate likelihood ratios that can be used along with estimating functions when any of these…