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结果延迟下的协变量调整响应自适应设计AI 解读

Covariate-adjusted response-adaptive (CARA) designs have gained widespread adoption for their clear benefits in enhancing experimental efficiency and participant welfare. These designs dynamically adjust treatment allocations during interim analyses based on participant responses and covariates collected during the experiment. However, delayed responses can significantly compromise the effectiveness of CARA designs, as they hinder timely adjustments to treatment assignments…

基于汇总数据、消除赢家诅咒的稳健孟德尔随机化AI 解读

In the past decade, the increased availability of genome-wide association studies summary data has popularized Mendelian Randomization (MR) for conducting causal inference. MR analyses, incorporating genetic variants as instrumental variables, are known for their robustness against reverse causation bias and unmeasured confounders. Nevertheless, classical MR analyses using summary data may still produce biased causal effect estimates due to the winner's curse and pleiotropy…

面向处理效应异质性学习的自适应实验AI 解读

Abstract Understanding treatment effect heterogeneity has become an increasingly popular task in various fields, as it helps design personalized advertisements in e-commerce or targeted treatment in biomedical studies. However, most of the existing work in this research area focused on either analysing observational data based on strong causal assumptions or conducting post hoc analyses of randomized controlled trial data, and there has been limited effort dedicated to the…

高效估计分位数处理效应的协变量调整响应自适应实验AI 解读

In program evaluation studies, understanding the heterogeneous distributional impacts of a program beyond the average effect is crucial. Quantile treatment effect (QTE) provides a natural measure to capture such heterogeneity. While much of the existing work for estimating QTE has focused on analyzing observational data based on untestable causal assumptions, little work has gone into designing randomized experiments specifically for estimating QTE. In this manuscript, we…

析因设计中的前向选择与选择后推断AI 解读

Ever since the seminal work of R. A. Fisher and F. Yates, factorial designs have been an important experimental tool to simultaneously estimate the effects of multiple treatment factors. In factorial designs, the number of treatment combinations grows exponentially with the number of treatment factors, which motivates the forward selection strategy based on the sparsity, hierarchy and heredity principles for factorial effects. Although this strategy is intuitive and has been…

基于回归秩得分的异质分位数处理效应去偏推断AI 解读

Abstract Understanding treatment effect heterogeneity is vital to many scientific fields because the same treatment may affect different individuals differently. Quantile regression provides a natural framework for modelling such heterogeneity. We propose a new method for inference on heterogeneous quantile treatment effects (HQTE) in the presence of high-dimensional covariates. Our estimator combines an ℓ1-penalised regression adjustment with a quantile-specific bias…

大量协变量下最优政策效应的推断AI 解读

Understanding the impact of the most effective policies or treatments on a response variable of interest is desirable in many empirical works in economics, statistics and other disciplines. Due to the widespread winner’s curse phenomenon, conventional statistical inference assuming that the top policies are chosen independent of the random sample may lead to overly optimistic evaluations of the best policies. In recent years, given the increased availability of large…

《流式纵向数据的统计推断》讨论回复AI 解读

We thank the editorial board for organizing this discussion and giving us the opportunity to explore experts’ perspectives on our work. We sincerely appreciate the discussants for their insightful contributions, which have raised many important points and provided suggestions for potential improvements and generalizations of our proposed method. In this rejoinder, we primarily focus on three important aspects raised by the discussants: (i) the role of the weighting parameter…

流式纵向数据的统计推断AI 解读

Summary Modern longitudinal data, for example from wearable devices, may consist of measurements of biological signals on a fixed set of participants at a diverging number of time-points. Traditional statistical methods are not equipped to handle the computational burden of repeatedly analysing the cumulatively growing dataset each time new data are collected. We propose a new estimation and inference framework for dynamic updating of point estimates and their standard…

识别他汀使用相关二型糖尿病风险最高的亚组：电子健康记录证据AI 解读

There have been increased concerns that the use of statins, one of the most commonly prescribed drugs for treating coronary artery disease, is potentially associated with the increased risk of new-onset Type II diabetes (T2D). Nevertheless, to date, there is no robust evidence supporting as to whether and what kind of populations are indeed vulnerable for developing T2D after taking statins. In this case study, leveraging the biobank and electronic health record data in the…

破解孟德尔随机化中的赢家诅咒：再随机化逆方差加权估计量AI 解读

Developments in genome-wide association studies and the increasing availability of summary genetic association data have made the application of two-sample Mendelian Randomization (MR) with summary data increasingly popular. Conventional two-sample MR methods often employ the same sample for selecting relevant genetic variants and for constructing final causal estimates. Such a practice often leads to biased causal effect estimates due to the well-known “winner’s curse”…

基于逆概率加权的稳健推断AI 解读

Inverse probability weighting (IPW) is widely used in empirical work in economics and other disciplines. As Gaussian approximations perform poorly in the presence of “small denominators,” trimming is routinely employed as a regularization strategy. However, ad hoc trimming of the observations renders usual inference procedures invalid for the target estimand, even in large samples. In this article, we first show that the IPW estimator can have different (Gaussian or…

高维模型中处理效应的去偏推断AI 解读

This article concerns the potential bias in statistical inference on treatment effects when a large number of covariates are present in a linear or partially linear model. While the estimation bias in an under-fitted model is well understood, we address a lesser-known bias that arises from an over-fitted model. The over-fitting bias can be eliminated through data splitting at the cost of statistical efficiency, and we show that smoothing over random data splits can be…