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Functional linear regression analysis for longitudinal data

纵向数据的函数型线性回归分析

We propose nonparametric methods for functional linear regression which are designed for sparse longitudinal data, where both the predictor and response are functions of a covariate such as time. Predictor and response processes have smooth random trajectories, and the data consist of a small number of noisy repeated measurements made at irregular times for a sample of subjects. In longitudinal studies, the number of repeated measurements per subject is often small and may…

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Functional Data Analysis for Sparse Longitudinal Data

稀疏纵向数据的函数型数据分析

We propose a nonparametric method to perform functional principal components analysis for the case of sparse longitudinal data. The method aims at irregularly spaced longitudinal data, where the number of repeated measurements available per subject is small. In contrast, classical functional data analysis requires a large number of regularly spaced measurements per subject. We assume that the repeated measurements are located randomly with a random number of repetitions for…

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Functional Quasi-Likelihood Regression Models with Smooth Random Effects

具有平滑随机效应的函数型准似然回归模型

Summary We propose a class of semiparametric functional regression models to describe the influence of vector-valued covariates on a sample of response curves. Each observed curve is viewed as the realization of a random process, composed of an overall mean function and random components. The finite dimensional covariates influence the random components of the eigenfunction expansion through single-index models that include unknown smooth link and variance functions. The…

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Dimension reduction for censored regression data

删失回归数据的降维

Without parametric assumptions, high-dimensional regression analysis is already complex. This is made even harder when data are subject to censoring. In this article, we seek ways of reducing the dimensionality of the regressor before applying nonparametric smoothing techniques. If the censoring time is independent of the lifetime, then the method of sliced inverse regression can be applied directly. Otherwise, modification is needed to adjust for the censoring bias. A key…

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Analysis of oldest-old mortality: lifetables revisited

最高龄死亡率分析:重新审视生命表

This paper provides a data analysis and some methodological advances which contribute to an ongoing scientific debate about the patterns of aging. One of the problems we address is how to estimate a hazard function when only aggregated information on the lifetimes in the form of a lifetable is available. This problem affects the the estimation of oldest-old mortality which in turn plays an important role in the quantification of biological lifespan and longevity. We…

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The jackknife estimate of a Kaplan—Meier integral

Kaplan–Meier积分的刀切法估计

We derive an explicit formula for the jackknife estimate of a Kaplan-Meier integral. From this the asymptotic analysis of the jackknifed Kaplan-Meier process becomes straightforward. In a small simulation study it is demonstrated that jackknifing may lead to a considerable reduction of the bias.

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A comparison of hazard rate estimators for left truncated and right censored data

左截断与右删失数据的风险率估计量比较

Left truncation and right censoring arise frequently in practice for life data. This paper is concerned with the estimation of the hazard rate function for such data. Two types of nonparametric estimators based on kernel smoothing methods are considered. The first one is obtained by convolving a kernel with a cumulative hazard estimator. The second one is in the form of a ratio of two statistics. Local properties including consistency, asymptotic normality and mean squared…

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Two-Sample Inference for Median Survival Times Based on One-Sample Procedures for Censored Survival Data

基于单样本程序的删失生存时间中位数双样本推断

Confidence intervals for median survival times are derived for censored survival data. The intervals are obtained by using the quantiles of the Kaplan-Meier product-limit estimator and have the same Pitman efficiency as the intervals found by inverting the sign test. Two-sample tests and confidence intervals for the difference in median survival times are then developed based on the comparison of the one-sample confidence intervals. Several methods for choosing the…

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Asymptotically Minimax Estimators for Distributions with Increasing Failure Rate

失效率递增分布的渐近极小极大估计量

We construct nonparametric estimators of the distribution function F and its hazard function in the class of all increasing failure rate (IFR) distribution. Denoting the empirical distribution and empirical hazard function by $F_n$ and $H_n$ , respectively, let $C_n$ be the greatest convex minorant of $H_n$, and $G_n$ the distribution with hazard function $C_n$. The estimator $G_n$ is itself IFR. We prove that under suitable restrictions on F, and for any fixed $\lambda$ with…

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Strong Consistency of Approximate Maximum Likelihood Estimators with Applications in Nonparametrics

近似最大似然估计的强一致性及其非参数应用

Wald's general analytic conditions that imply strong consistency of the approximate maximum likelihood estimators (AMLEs) have been extended by Le Cam, Kiefer and Wolfowitz, Huber, Bahadur, and Perlman. All these conditions use the log likelihood ratio of the type $\log\lbrack f(x, \theta)/f(x, \theta_0)\rbrack$, where $\theta_0$ is the true value of the parameter. However these methods usually fail in the nonparametric case. Thus, in this paper, for each $\theta \neq \theta_0$…

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