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半参数效率及其对群组序贯研究设计与分析的意义AI 解读

Authors have shown that the time-sequential joint distributions of many statistics used to analyze data arising from group-sequential time-to-event and longitudinal studies are multivariate normal with an independent increments covariance structure. In Theorem 1 of this article, we demonstrate that this limiting distribution arises naturally when one uses an efficient test statistic to test a single parameter in a semiparametric or parametric model. Because we are able to…

利用工具变量识别因果效应：评论AI 解读

We outline a framework for causal inference in settings where assignment to a binary treatment is ignorable, but compliance with the assignment is not perfect so that the receipt of treatment is nonignorable. To address the problems associated with comparing subjects by the ignorable assignment-an intention-to-treat analysis-we make use of instrumental variables, which have long been used by economists in the context of regression models with constant treatment effects. We…

存在依赖删失时的半参数回归估计AI 解读

We propose a semiparametric estimation procedure for estimating the regression of an outcome Y, measured at the end of a fixed follow-up period, on baseline explanatory variables X, measured prior to start of follow-up, in the presence of dependent censoring given X. The proposed estimators are consistent when the data are ‘missing at random’ but not ‘missing completely at random’ (Rubin, 1976), and do not require full specification of the complete data likelihood.…

协变量缺失或误测时条件密度的半参数有效估计AI 解读

SUMMARY Pepe and Fleming, and Carroll and Wand have recently proposed estimators in a parametric model for the density of a random variable Y conditional on a vector of covariates (X, V) when data on one of the regressors X is missing for some study subjects. We propose a new class of estimators that remains consistent and asymptotically normal even when the probability that X is missing depends on the observed V and Y, includes an estimator whose asymptotic variance attains…

缺失数据下多元回归模型的半参数效率AI 解读

We consider the efficiency bound for the estimation of the parameters of semiparametric models defined solely by restrictions on the means of a vector of correlated outcomes, Y, when the data on Y are missing at random. We show that the semiparametric variance bound is the asymptotic variance of the optimal estimator in a class of inverse probability of censoring weighted estimators and that this bound is unchanged if the data are missing completely at random. For this case…

缺失数据下重复结局半参数回归模型的分析AI 解读

We propose a class of inverse probability of censoring weighted estimators for the parameters of models for the dependence of the mean of a vector of correlated response variables on a vector of explanatory variables in the presence of missing response data. The proposed estimators do not require full specification of the likelihood. They can be viewed as an extension of generalized estimating equations estimators that allow for the data to be missing at random but not…

依赖删失下的半参数回归估计AI 解读

We propose a semiparametric estimation procedure for estimating the regression of an outcome Y, measured at the end of a fixed follow-up period, on baseline explanatory variables X, measured prior to start of follow-up, in the presence of dependent censoring given X. The proposed estimators are consistent when the data are ‘missing at random’ but not ‘missing completely at random’ (Rubin, 1976), and do not require full specification of the complete data likelihood.…

部分回归变量并非始终可观测时的回归系数估计AI 解读

In applied problems it is common to specify a model for the conditional mean of a response given a set of regressors. A subset of the regressors may be missing for some study subjects either by design or happenstance. In this article we propose a new class of semiparametric estimators, based on inverse probability weighted estimating equations, that are consistent for parameter vector α0 of the conditional mean model when the data are missing at random in the sense of Rubin…