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Sequential Nonparametric Tests for a Change in Distribution: An Application to Detecting Radiological Anomalies

分布变化的序贯非参数检验:放射性异常检测应用

We propose a sequential nonparametric test for detecting a change in distribution, based on windowed Kolmogorov–Smirnov statistics. The approach is simple, robust, highly computationally efficient, easy to calibrate, and requires no parametric assumptions about the underlying null and alternative distributions. We show that both the false-alarm rate and the power of our procedure are amenable to rigorous analysis, and that the method outperforms existing sequential testing…

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False Discovery Rate Smoothing

错误发现率平滑

We present false discovery rate (FDR) smoothing, an empirical-Bayes method for exploiting spatial structure in large multiple-testing problems. FDR smoothing automatically finds spatially localized regions of significant test statistics. It then relaxes the threshold of statistical significance within these regions, and tightens it elsewhere, in a manner that controls the overall false discovery rate at a given level. This results in increased power and cleaner spatial…

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Multiscale Spatial Density Smoothing: An Application to Large-Scale Radiological Survey and Anomaly Detection

多尺度空间密度平滑:大规模辐射调查与异常检测应用

We consider the problem of estimating a spatially varying density function, motivated by problems that arise in large-scale radiological survey and anomaly detection. In this context, the density functions to be estimated are the background gamma-ray energy spectra at sites spread across a large geographical area, such as nuclear production and waste-storage sites, military bases, medical facilities, university campuses, or the downtown of a city. Several challenges combine…

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Mixtures, Envelopes and Hierarchical Duality

混合表示、包络表示与层级对偶

Summary We develop a connection between mixture and envelope representations of objective functions that arise frequently in statistics. We refer to this connection by using the term ‘hierarchical duality’. Our results suggest an interesting and previously underexploited relationship between marginalization and profiling, or equivalently between the Fenchel–Moreau theorem for convex functions and the Bernstein–Widder theorem for Laplace transforms. We give several different…

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Priors for Random Count Matrices Derived from a Family of Negative Binomial Processes

由负二项过程族构造的随机计数矩阵先验

We define a family of probability distributions for random count matrices with a potentially unbounded number of rows and columns. The three distributions we consider are derived from the gamma-Poisson, gamma-negative binomial, and beta-negative binomial processes, which we refer to generically as a family of negative-binomial processes. Because the models lead to closed-form update equations within the context of a Gibbs sampler, they are natural candidates for…

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False Discovery Rate Regression: An Application to Neural Synchrony Detection in Primary Visual Cortex

错误发现率回归及初级视觉皮层神经同步检测应用

Many approaches for multiple testing begin with the assumption that all tests in a given study should be combined into a global false-discovery-rate analysis. But this may be inappropriate for many of today's large-scale screening problems, where auxiliary information about each test is often available, and where a combined analysis can lead to poorly calibrated error rates within different subsets of the experiment. To address this issue, we introduce an approach called…

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The Bayesian Bridge

贝叶斯桥估计

Summary We propose the Bayesian bridge estimator for regularized regression and classification. Two key mixture representations for the Bayesian bridge model are developed: a scale mixture of normal distributions with respect to an α-stable random variable; a mixture of Bartlett–Fejer kernels (or triangle densities) with respect to a two-component mixture of gamma random variables. Both lead to Markov chain Monte Carlo methods for posterior simulation, and these methods turn…

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Bayesian Inference for Logistic Models Using Pólya–Gamma Latent Variables

利用 Pólya–Gamma 潜变量进行逻辑模型贝叶斯推断

We propose a new data-augmentation strategy for fully Bayesian inference in models with binomial likelihoods. The approach appeals to a new class of Pólya–Gamma distributions, which are constructed in detail. A variety of examples are presented to show the versatility of the method, including logistic regression, negative binomial regression, nonlinear mixed-effect models, and spatial models for count data. In each case, our data-augmentation strategy leads to simple,…

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Local Shrinkage Rules, Lévy Processes and Regularized Regression

局部收缩规则、Lévy 过程与正则化回归

Summary We use Lévy processes to generate joint prior distributions, and therefore penalty functions, for a location parameter β=(β1,…,βp) as p grows large. This generalizes the class of local–global shrinkage rules based on scale mixtures of normals, illuminates new connections between disparate methods and leads to new results for computing posterior means and modes under a wide class of priors. We extend this framework to large-scale regularized regression problems where…

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Bayes and empirical-Bayes multiplicity adjustment in the variable-selection problem

变量选择中贝叶斯与经验贝叶斯的多重性调整

This paper studies the multiplicity-correction effect of standard Bayesian variable-selection priors in linear regression. Our first goal is to clarify when, and how, multiplicity correction happens automatically in Bayesian analysis, and to distinguish this correction from the Bayesian Ockham’s-razor effect. Our second goal is to contrast empirical-Bayes and fully Bayesian approaches to variable selection through examples, theoretical results and simulations. Considerable…

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