Joint Estimation of Treatment and Placebo Effects in Clinical Trials With Longitudinal Blinding Assessments
利用纵向盲法评估联合估计治疗效应与安慰剂效应
In some therapeutic areas, treatment evaluation is frequently complicated by a possible placebo effect (i.e., the psychobiological effect of a patient's knowledge or belief of being treated). When a substantial placebo effect is likely to exist, it is important to distinguish the treatment and placebo effects in quantifying the clinical benefit of a new treatment. These causal effects can be formally defined in a joint causal model that includes treatment (e.g., new versus…